How Postbiotics Upgrade Your Mitochondria – Dr. Anurag Singh – #877


Dr. Singh has spent seven years focused on Urolithin A research and clinical trials. His initial round of research with Urolithin A showed that it could increase aerobic endurance and increase grip strength.

Urolithin A also is the first postbiotic shown to repair mitochondrial health via mitophagy. Mitophagy is the process of renewing your mitochondrial growth as you age. As healthy mitochondria get older they accumulate free radicals and reactive oxygen species. They lose shape and stop communicating with one another, too. These faulty mitochondria have need to be replaced. Urolithin A revs up the mitochondrial recycling.

He explains how you can get the benefits of Urolithin A and how to take it to achieve results.

“Our gut microbiome is very complex ecosystem with hundreds of millions of different species interacting with each other,” explains Dr. Singh. “They need to be interacting in perfect harmony to release these postbiotics, which is the way I look at it is the perfect gut health relationship within the microbiome. So it’s not one bacteria. It’s not one strain that you can isolate and give. It’s really got to be multi-species. I think you can probably conceptually find that strain or probiotic that could do it, but the process will be so inefficient that the best way is to short circuit it and provide the postbiotic, which is Urolithin A, directly in a pill or in a food product.”

Another direction for Urolithin A is sports performance. Amazentis teamed up with renowned researcher Dr. Louise Burke in Australia to look into how Urolithin A affects mitochondrial health in athletes. Those results will be available in 2022.

The future of Urolithin research keeps going in exciting new directions, including brain health.

“So, there’s a lot of research going on around this molecule,” Dr. Singh says. “[The] Buck Institute of Aging in California just got a multimillion grant from the National Institute of Health to study the effects of Urolithin A on the cognitive aging and how it can reverse some of the neuronal circuitry to look youthful. So we are actively looking at it and keeping our eyes and ears open for exactly feedback like this because brain cells also after muscle cells have the highest number of mitochondria that decline with aging.”

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